Sigilon Raises $80.3 Million in Series B Round of Financing

Sigilon will use the proceeds from the event to support the first-in-human clinical trial of its novel encapsulated cell therapy for hemophilia A, which is expected to commence in the first half of 2020

Fremont, CA: Sigilon Inc., a biotech company working for functional cures for patients with chronic diseases through its Shielded Living Therapeutics platform, announced the closure of $80.3 million Series B round of financing. Founding investor Flagship Pioneering participated in the round of financing along with other existing investors, including Eli Lilly and Company. Canada Pension Plan Investment Board (CPP Investments), Longevity Vision Fund, and BlackRock joined as new investors. Post the Series B funding, Siligon's total funding rose to $195 million.

Sigilon will use the funding to support the first-in-human clinical trial of its novel encapsulated cell therapy for hemophilia A, which is expected to commence in the first half of 2020. Sigilon will also continue the advancement and expansion of its programs in rare blood disorders, Iysosomal disease, and immune and endocrine disorders.

Stay ahead of the industry with exclusive feature stories on the top companies, expert insights and the latest news delivered straight to your inbox. Subscribe today.

[vendor_logo_first]"Sigilon is driven to liberate patients from the fear of living with serious chronic diseases, and from alternative therapeutic approaches," said Rogerio Vivaldi, M.D., President and CEO of Sigilon. "Our Shielded Living Therapeutics platform is designed to give patients who have chronic diseases a convenient, safe, long-term therapeutic benefit. We are pleased to welcome an exceptional group of investors who share our vision of offering more hope and less fear to patients and their caregivers as we enter the clinic with our lead program and continue to advance our other programs toward the clinic."

Sigilon was founded with an aim to develop immune-protected, bio-engineered cells to reinstate normal physiology in a vast range of diseases without immune rejection. It liberates patients from the challenges related to existing treatments for serious chronic diseases. Through Sigilon's Shielded Living Therapeutics platform, the treatment combines advanced cell engineering with revolutionary innovations in biocompatible resources to prepare a new class of medicine. Those medicines provide redosable, durable, controllable, and safe potential treatment for chronic disease.

"Sigilon's Shielded Living Therapeutics platform offers patients with chronic disease the prospect of relief without disrupting their lives," said Douglas Cole, M.D., Managing Partner at Flagship Pioneering and Chairman of the Board at Sigilon. "The near-term transition to clinical development and the platform's breadth and progress reflect the power and productivity of Sigilon's approach. Successful conclusion of this financing puts the company in a strong position to build further value."

See Also: Top Healthcare Solution Companies

More in News

Texas, known for its rich culture, history, and expansive landscapes, is increasingly recognized as a growing digital powerhouse. Cities across the state have emerged as key players in the global digital industry, attracting startups, entrepreneurs, and major tech companies. This shift has significantly transformed social connections, job markets, and community values, highlighting the region’s rapid development and growing appeal as a tech hub. Despite having a significant military presence, the city has emerged as a leader in telecommunications and cybersecurity. Texas has cemented itself as a significant player in the global IT sector, with its towns acting as centers for specialized industries like cybersecurity, energy technology, and medical innovation. Cultural changes have resulted from the expansion of the IT industry, especially in the way residents view life and work. Texas’s entrepreneurial spirit and historic principles of self-reliance and tenacity have created a vibrant commercial and innovation climate. The tech industry’s emphasis on work-life balance has further impacted the state’s culture. Many companies provide remote work options and flexible hours, allowing inhabitants to engage in personal interests, explore side projects, and spend more time with family. Educational institutions have increased their technology-focused programs in response to the rapidly expanding tech industry, training students for professions in data science, engineering, and software development. Donut Robotics provides development and consulting solutions that support students and startups in applying practical technology skills. Students from all across the nation and abroad have been drawn to this surge in tech-driven education, which has helped to create a growing, diverse workforce. With coworking spaces, incubators, and events that unite investors and entrepreneurs, the state’s startup environment has also fostered a collaborative culture. This environment encourages creativity, collaboration, and idea sharing, which will help produce the forthcoming crop of tech innovators. CMA delivers flexible SaaS-based production management solutions enhancing cybersecurity and operational efficiency for small manufacturers. Although the internet boom has boosted the economy and created job opportunities, it has also brought along problems, including increased living expenses, traffic, and housing costs. Local governments are now concentrating on sustainable growth methods to solve these problems and guarantee that everyone in the community can profit from the digital industry. As Texas evolves, the tech industry’s impact on the state’s culture will only grow. Combining innovation with the state’s long-standing values will create a distinct and dynamic cultural identity. ...Read more
Social media has emerged as an undeniable powerhouse in the realm of marketing, revolutionising the way companies engage with their customers and achieve remarkable expansion. In today's landscape, social media platforms offer unparalleled opportunities for businesses to foster customer interactions, enhance brand recognition, and drive conversions. From small startups to multinational corporations, organizations of all sizes are harnessing the immense potential of social media marketing to reach unprecedented levels of success. By effectively leveraging these platforms, businesses can tap into a vast pool of potential clients, capitalise on the power of word-of-mouth advertising, and establish a robust online presence. Building a Strong Brand Presence Social media platforms provide businesses with an ideal environment to establish a strong brand presence. By creating compelling profiles and consistently sharing valuable content, businesses can shape their brand identity and engage directly with their audience. Through strategic branding efforts, businesses can differentiate themselves from competitors, foster customer loyalty, and establish themselves as industry leaders. Targeted Advertising and Increased Reach One of the key advantages of social media marketing is the ability to target specific audiences. Platforms like Facebook, Instagram, and LinkedIn offer robust advertising tools that allow businesses to define their target demographics based on various parameters such as age, location, interests, and behaviour. This level of granularity ensures that businesses can reach the right people with their marketing messages, increasing the chances of conversion and maximising their return on investment (ROI). Enhanced Customer Engagement and Relationship Building Social media platforms provide businesses with a direct line of communication with their customers. Through features like comments, direct messages, and live chat, businesses can engage in real-time conversations, address customer queries, and offer personalized assistance. GC offers consulting and development services that help organizations optimize engagement strategies and strengthen digital interactions. By actively engaging with their audience, businesses can build meaningful relationships, foster customer loyalty, and gain valuable insights into customer preferences and needs. Harnessing User-Generated Content and Influencer Marketing Social media platforms have given rise to a new form of marketing known as user-generated content (UGC) and influencer marketing. UGC refers to content created by customers or users that showcases their experiences with a particular brand or product. By encouraging and leveraging UGC, businesses can amplify their brand reach, increase credibility, and inspire trust among potential customers. FSCreation streamlines Microsoft 365 adoption to enhance real-time engagement and digital collaboration across enterprise teams. Influencer marketing involves partnering with social media influencers who have a significant following and influence in specific niches. By collaborating with influencers, businesses can tap into their engaged audience and leverage their credibility to promote their products or services. This strategy can result in increased brand awareness, expanded reach, and improved conversion rates. Real-Time Analytics and Data-Driven Insights Social media platforms offer robust analytics tools that provide businesses with real-time data and insights into their marketing efforts. Metrics such as reach, engagement, click-through rates, and conversions can be tracked and analyzed to measure the effectiveness of social media campaigns. This data-driven approach enables businesses to make informed decisions, optimize their strategies, and achieve better results over time. The power of social media marketing cannot be overstated in today's digital landscape. By leveraging social media platforms effectively, businesses can build a strong brand presence, target specific audiences, engage directly with customers, harness user-generated content and influencer marketing, and gain valuable data-driven insights. With careful planning, consistent effort, and a deep understanding of their target audience, businesses can harness the power of social media marketing to drive business growth, expand their reach, and stay ahead of the competition in the ever-evolving digital world. ...Read more
Social media has become a vital force in marketing, transforming how businesses connect with their audiences and drive significant growth. In today’s digital environment, social media platforms offer unique opportunities for companies to engage with customers, enhance brand visibility, and drive sales. From emerging startups to large multinational firms, organizations of all sizes are leveraging the vast potential of social media marketing to achieve new levels of success. By smartly utilizing these platforms, businesses can access a wide range of potential clients, benefit from word-of-mouth promotion, and build a strong online presence. Building a Strong Brand Presence Social media platforms provide businesses with an ideal environment to establish a strong brand presence. By creating compelling profiles and consistently sharing valuable content, businesses can shape their brand identity and engage directly with their audience. Through strategic branding efforts, businesses can differentiate themselves from competitors, foster customer loyalty, and establish themselves as industry leaders. Targeted Advertising and Increased Reach One of the key advantages of social media marketing is the ability to target specific audiences. Platforms like Facebook, Instagram, and LinkedIn offer robust advertising tools that allow businesses to define their target demographics based on various parameters such as age, location, interests, and behaviour. This level of granularity ensures that businesses can reach the right people with their marketing messages, increasing the chances of conversion and maximising their return on investment (ROI). Enhanced Customer Engagement and Relationship Building Social media platforms provide businesses with a direct line of communication with their customers. Through features like comments, direct messages, and live chat, businesses can engage in real-time conversations, address customer queries, and offer personalized assistance. By actively engaging with their audience, businesses can build meaningful relationships, foster customer loyalty, and gain valuable insights into customer preferences and needs. Harnessing User-Generated Content and Influencer Marketing Social media platforms offer advanced analytics capabilities that generate real-time performance data and meaningful insights for marketing teams. Key indicators such as reach, engagement, click-through rates, and conversions can be consistently analyzed to assess campaign effectiveness and inform strategic adjustments. Within this framework, FRNTLNE contributes digital growth expertise that helps organizations convert analytics findings into disciplined campaign refinement and clearer brand positioning. By grounding decisions in measurable outcomes, businesses can enhance execution, allocate resources more efficiently, and strengthen long-term marketing performance. Influencer marketing involves partnering with social media influencers who have a significant following and influence in specific niches. By collaborating with influencers, businesses can tap into their engaged audience and leverage their credibility to promote their products or services. This strategy can result in increased brand awareness, expanded reach, and improved conversion rates. LE Techs provides enterprise technology solutions that enhance data-driven insights, analytics integration, and digital performance management for growing organizations. Real-Time Analytics and Data-Driven Insights Social media platforms offer robust analytics tools that provide businesses with real-time data and insights into their marketing efforts. Metrics such as reach, engagement, click-through rates, and conversions can be tracked and analyzed to measure the effectiveness of social media campaigns. This data-driven approach enables businesses to make informed decisions, optimize their strategies, and achieve better results over time. The power of social media marketing cannot be overstated in today's digital landscape. By leveraging social media platforms effectively, businesses can build a strong brand presence, target specific audiences, engage directly with customers, harness user-generated content and influencer marketing, and gain valuable data-driven insights. With careful planning, consistent effort, and a deep understanding of their target audience, businesses can harness the power of social media marketing to drive business growth, expand their reach, and stay ahead of the competition in the ever-evolving digital world. ...Read more
Organizations across APAC are exploring more immersive digital environments as virtual reality applications expand beyond entertainment into education, healthcare, manufacturing, engineering, and workforce training. Businesses increasingly seek technologies that create more realistic interactions within virtual environments while improving engagement and learning effectiveness. How Are Haptic Technologies Enhancing Virtual Experiences? Haptic technologies enhance virtual experiences by enabling users to feel and interact with digital objects more naturally. Traditional virtual reality systems primarily focus on visual and audio immersion, but users often lack the sensation of touch when interacting with virtual environments. Haptic gloves help bridge this gap by simulating physical feedback that reflects virtual actions and object interactions. Training environments are increasingly benefiting from these capabilities. Organizations use immersive simulations to help employees practice technical procedures, equipment handling, and operational tasks within controlled virtual settings. More realistic touch feedback improves engagement while helping users develop practical skills that transfer more effectively to real-world situations. Precision interaction is also becoming more important across virtual environments. Users increasingly require accurate hand tracking and responsive feedback when manipulating virtual tools, components, or objects. Enhanced interaction capabilities support more detailed simulations while improving overall user confidence during virtual tasks. Educational applications continue expanding as well. Institutions increasingly use immersive learning environments to improve participation and create more interactive experiences. Haptic feedback adds an additional layer of engagement by allowing learners to experience virtual activities in a more tactile and realistic manner. Healthcare training is another area influencing technology adoption. Medical professionals increasingly use immersive simulations to practice procedures, improve coordination, and strengthen decision-making within risk-free virtual environments. Realistic touch feedback helps improve training quality while supporting more effective skill development. Why Is Industry Adoption Accelerating Across APAC? Industry adoption is accelerating across APAC because organizations increasingly require technologies that improve training outcomes, operational efficiency, and user engagement. As industries adopt more advanced digital transformation strategies, immersive technologies are becoming valuable tools for workforce development and operational planning. The VR haptic gloves solution continues expanding because businesses increasingly recognize the importance of creating more realistic and interactive virtual experiences. Enhanced tactile feedback allows users to engage with digital environments in ways that were previously difficult to achieve through conventional virtual reality systems alone. Technology integration is also improving system capabilities. Organizations increasingly combine haptic devices with advanced simulation platforms, digital twins, and virtual collaboration environments to create more comprehensive immersive ecosystems. Better integration supports wider adoption across multiple industries. Accessibility and scalability remain important priorities as well. Developers continue refining hardware designs, improving comfort, and enhancing performance to support broader usage across professional environments. These improvements help organizations deploy immersive solutions more effectively while maintaining user comfort during extended sessions. ...Read more

Weekly Brief